Search:
  高级检索   全部    有全文
现在位置: 首页 > 检索 >演示文稿 > 
∆N-p63 functions as an invasion, migration, and metastasis suppressor
Lakshmanane Boominathan
doi/hdl:10101/npre.2010.4771.1
原文下载:

文摘:The tumor suppressor p53 homologues, TA-p73, and p63 have been shown to function as tumor suppressors. However, how they function as tumor suppressors remains elusive. Expression of p63 is controlled by two distinct promoters. Consequently, this results in two different gene products such as TA-(transactivation domain containing NH2 terminus) p63 and ∆N-(lacks NH2 terminus) p63. It is generally thought that the TA-p63 functions as a tumor suppressor, while the ∆N-p73 functions as a proto-oncogene. However, careful interpretation of the data concerning ∆N-p63 suggests that it could function as an invasion and metastasis/tumor suppressor in a cell context dependent manner.

文档类型:Manuscript
日期:2010
学科分类:cancer
资源类型:演示文稿
权限:Creative Commons Attribution 3.0 License
原文链接:http://precedings.nature.com/documents/4771/version/1
内容提供者:NaturePrecedings

浏览量:633    下载量:62