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EBV-positive diffuse large B-cell lymphoma in a patient with primary Sj??gren???s syndrome and membranous glomerulonephritis
Eun Hui Bae; Seong Kwon Ma; Chang Seong Kim; Yoo Duk Choi; Soo Wan Kim; Joon Seok Choi
BMC Nephrology,13,1(2012-11-15)
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摘要:

Background

Sj??gren???s syndrome is a systemic autoimmune disease in which lymphatic cells destroy the salivary and lacrimal glands. Glomerulonephritis is thought to be a rare occurrence in primary Sj??gren???s syndrome. Furthermore, concurrent glomerular involvement and lymphoma in patients with Sj??gren???s syndrome has seldom been reported.

Case presentation

A 52-year-old woman with primary Sj??gren???s syndrome developed membranous glomerulonephritis and Epstein-Barr virus-positive diffuse large B-cell lymphoma (DLBCL). She was diagnosed with Sj??gren???s syndrome based on the dry eyes, dry mouth, positive anti-nuclear antibody test, anti-Ro (SS-A) antibody, salivary gland biopsy, and salivary scintigraphy. Moreover, renal biopsy confirmed the diagnosis of membranous glomerulonephritis. Three months later, her small bowel was perforated with pneumoperitoneum, and the biopsy revealed Epstein-Barr virus-positive DLBCL.

Conclusions

We observed the first case of primary Sj??gren???s syndrome associated with Epstein-Barr Virus-positive DLBCL and membranous glomerulonephritis. Because of the possibility of malignancy-associated membranous glomerulonephritis in patients with primary Sj??gren???s syndrome, we should be careful and examine such patients for hidden malignancy.

关键词:Membranous glomerulonephritis, EBV-positive diffuse large B-cell lymphoma, Primary Sj??gren???s syndrome

出版者:BioMed Central Ltd
出版日期:2012-11-15
资源类型:期刊论文
学科分类:Urology;Nephrology
语种:en
授权许可:http://creativecommons.org/licenses/by/2.0/
本地全文:http://gooa.las.ac.cn/external/index?type=-1&pid=1083062
内容提供者:开放获取论文一站式发现平台(GoOA)

推荐引用方式:Eun Hui Bae,Seong Kwon Ma,Chang Seong Kim, et al. EBV-positive diffuse large B-cell lymphoma in a patient with primary Sj??gren???s syndrome and membranous glomerulonephritis[J]. BMC Nephrology,2012,13(1)

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