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Mineral and bone disorder in Chinese dialysis patients: a multicenter study
Feng Ding; Jinyuan Zhang; Zuying Xiong; Xiangmei Chen; Luxia Zhang; Liqun He; Minhua Fan; Wei Chen; Hua Wu; Weijie Yuan; Xianglei Kong; Liren Peng; Jianghua Chen; Wenhu Liu; Xueqing Yu; Haiyan Wang; Mei Wang; Li Zuo; Zhaohui Ni; Dongmei Xu; Li Wang; Yong Gu; Nan Chen; Changlin Mei; Guiyang Shu; Fanfan Hou; Xiaoling Tang; Ling Zhang; Changying Xing; Wei Shi; Qiang Jia
BMC Nephrology,13,1(2012-09-21)



Mineral and bone disorder (MBD) in patients with chronic kidney disease is associated with increased morbidity and mortality. Studies regarding the status of MBD treatment in developing countries, especially in Chinese dialysis patients are extremely limited.


A cross-sectional study of 1711 haemodialysis (HD) patients and 363 peritoneal dialysis (PD) patients were enrolled. Parameters related to MBD, including serum phosphorus (P), calcium (Ca), intact parathyroid hormone (iPTH) were analyzed. The achievement of MBD targets was compared with the results from the Dialysis Outcomes and Practice Study (DOPPS) 3 and DOPPS 4. Factors associated with hyperphosphatemia were examined.


Total 2074 dialysis patients from 28 hospitals were involved in this study. Only 38.5%, 39.6% and 26.6% of them met the Kidney Disease Outcomes Quality Initiative (K/DOQI) defined targets for serum P, Ca and iPTH levels. Serum P and Ca levels were statistically higher (P???<???0.05) in the HD patients compared with those of PD patients, which was (6.3????????2.1) mg/dL vs (5.7????????2.0) mg/dL and (9.3????????1.1) mg/dL vs (9.2????????1.1) mg/dL, respectively. Serum iPTH level were statistically higher in the PD patients compared with those of HD patients (P???=???0.03). The percentage of patients reached the K/DOQI targets for P (37.6% vs 49.8% vs 54.5%, P???<???0.01), Ca (38.6% vs 50.4% vs 56.0%, P???<???0.01) and iPTH (26.5% vs 31.4% vs 32.1%, P???<???0.01) were lower among HD patients, compared with the data from DOPPS 3 and DOPPS 4. The percentage of patients with serum phosphorus level above 5.5 mg/dL was 57.4% in HD patients and 47.4% in PD patients. Age, dialysis patterns and region of residency were independently associated with hyperphosphatemia.


Status of MBD is sub-optimal among Chinese patients receiving dialysis. The issue of hyperphosphatemia is prominent and needs further attention.

关键词:Epidemiology, Mineral and bone disorder, End stage renal disease

出版者:BioMed Central Ltd

推荐引用方式:Feng Ding,Jinyuan Zhang,Zuying Xiong, et al. Mineral and bone disorder in Chinese dialysis patients: a multicenter study[J]. BMC Nephrology,2012,13(1)

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